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Ménière's disease is a viral neuropathy.

TitleMénière's disease is a viral neuropathy.
Publication TypeJournal Article
Year of Publication2009
AuthorsGacek RR
JournalORL J Otorhinolaryngol Relat Spec
Date Published2009
KeywordsAged, Aged, 80 and over, Endolymphatic Hydrops, Female, Humans, Male, Meniere Disease, Microscopy, Electron, Transmission, Middle Aged, Severity of Illness Index, Spiral Ganglion, Vestibular Neuronitis, Vestibule, Labyrinth

<p>Morphological and clinical evidence supports a viral neuropathy in Ménière's disease (MD). Quantitative examination of 11 sectioned temporal bones (TBs) from 8 patients with a history of MD revealed a significant loss of vestibular ganglion cells in both the endolymph hydropic (EH) and non-EH ears. Transmission electron microscopy of vestibular ganglion cells excised from a patient with MD revealed viral particles enclosed in transport vesicles. Antiviral treatment controlled vertigo in 73 of 86 patients with vestibular neuronitis (85%) and 32 of 35 patients with MD (91%).</p>

Alternate JournalORL J. Otorhinolaryngol. Relat. Spec.
Citation KeyCK29
PubMed ID19142031