Gacek, Richard R

M'eni`eretextquoterights disease is a viral neuropathy. Journal Article

ORL J Otorhinolaryngol Relat Spec, 71 , pp. 78-86, 2009, ISSN: 1423-0275.

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Abstract

Morphological and clinical evidence supports a viral neuropathy in M'eni`eretextquoterights disease (MD). Quantitative examination of 11 sectioned temporal bones (TBs) from 8 patients with a history of MD revealed a significant loss of vestibular ganglion cells in both the endolymph hydropic (EH) and non-EH ears. Transmission electron microscopy of vestibular ganglion cells excised from a patient with MD revealed viral particles enclosed in transport vesicles. Antiviral treatment controlled vertigo in 73 of 86 patients with vestibular neuronitis (85%) and 32 of 35 patients with MD (91%).