Carey, John

Intratympanic gentamicin for the treatment of Menieretextquoterights disease and other forms of peripheral vertigo. Journal Article

Otolaryngol Clin North Am, 37 , pp. 1075-90, 2004, ISSN: 0030-6665.

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Titration therapy with intratympanic gentamicin offers class A or B control of vertigo in 87% (range, 75%-100%) of patients with unilateral M'eni`eretextquoterights disease. The risk of additional hearing loss is about 21% (range,0-37%). Vertigo may recur, however, in nearly one third of patients over time. These recurrences can also be treated by intratympanic gentamicin with a similar risk of hearing loss. The salient effect of intratympanic gentamicin is probably the reduction of vestibular function through damage to hair cells, but a complete ablation of function does not seem to be necessary for vertigo control.